New research indicates that individuals who come off blockbuster GLP-1 drugs like semaglutide or tirzepatide may regain shed pounds far faster than those who stop traditional diet and exercise programs.
Research printed in a prominent health publication points out that while overweight individuals frequently drop substantial amounts of their total mass while undergoing treatment, the weight comes back at an average rate of nearly a kilo each month after stopping.
"Users buying such treatments need to be cognizant of the risk of fast rebound weight gain when the treatment concludes," stated expert Dr. Susan Jebb.
This pace of regain implies a reversion to starting mass in about a year and a half.
Comparing Treatments
The analysis, which reviewed 37 of studies involving over 9,000 of participants, contrasted the effects of the injectable medications with older methods.
The team emphasize that individuals who shed pounds through lifestyle changes alone generally have a more gradual weight regain—perhaps 0.1 kg a month—after stopping.
Explaining the Quick Regain
Experts believe the way of the drugs is key to understanding the heightened rebound.
The injections mimic a natural hormone called GLP-1, which moderates hunger.
"Long-term administration of the hormone levels several times higher than the body's typical production may cause the body to produce less of its own natural GLP-1, and could reduce responsiveness to its effects," noted Dr. Adam Collins, a dietetics expert.
"Withdrawal of this GLP-1 'fix' results in hunger is uncontrolled, making binge eating far more likely."
An Ongoing Issue?
Health authorities recommend the injections for people with obesity-related medical conditions, accompanied by recommended lifestyle changes.
Professionals argue that, considering the high risk of relapse, the treatment is often life-long.
This opinion is echoed by pharmaceutical companies, who state that the results "highlight the persistent character of excess weight," akin to managing diseases like diabetes.
User Accounts
Individuals who have stopped the jabs report a sudden resurgence of hunger.
"It was like something that goes on and you become starving," recalled an individual.
This challenge is worsened if users have not developed permanent dietary or behavioural changes during treatment.
Growing Interest
Recent estimates indicate that a significant number of adults in the UK have tried these injections in the past year, with demand continuing to grow.
- Use is greater among women than men.
- The middle-aged age group shows the greatest usage rates.
- A large proportion obtain the medications through private healthcare rather than the NHS.
In conclusion, researchers emphasize that while the jabs are powerful agents for shedding pounds, they are not a magic fix and lasting health benefits relies on combined behavioural changes.
